MODULATORS OF DRUG DEPENDENCE PHENOMENA

Factors Affecting Morphine Withdrawal Syndrome and Cocaine-intake in Rodents

Outline of the studies

Abbreviations

PART 1: Drug Dependence and Harmful Use of Drugs

Chapter 1???Definition of terms and classification of dependence-producing drugs

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PART 2: Opioid Dependence

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Chapter 2???Opioids

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PART 3: Morphine Withdrawal Syndrome - Experimental Studies?

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Chapter 3???Excitatory amino acid receptor antagonists and naloxoneprecipitated withdrawal syndrome in morphine-dependent mice?

SLT Cappendijk, R de Vries and MR Dzoljic European Neuropsychopharmacology 3: 111-116,1993

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Chapter 4???Inhibitory effect of nitric oxide (NO) synthase inhibitors on naloxone-precipitated withdrawal syndrome in morphinedependent mice??

SLT Cappendijk, R de Vries and MR Dzoljic Neuroscience Letters 162: 97-100, 1993

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Chapter 5???Comparative study of normotensive and hypertensive nitric oxide synthase inhibitors on morphine withdrawal syndrome in rats SLT Cappendijk, SY Duval, R de Vries and MR Dzoljic Neuroscience Letters 183: 67-70, 1995

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Chapter 6???"Withdrawal substance" in cerebrospinal fluid of morphineabstinent rats?

SLT Cappendijk, J Silberring, R de Vries and MR Dzoljic Submitted for publication, 1994 Short communication: Regulatory Peptides 1: S227-228, 1994

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Chapter 7??The inhibitory effect of norharman on morphine withdrawal sydrome in rats - comparison with ibogaine?

SLT Cappendijk, D Fekkes, R de Vries and MR Dzoljic Behavioural Brain Research 65: 117-119, 1994 Short communication: Regulatory Peptides 54: 39-40, 1994?

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PART 4: Drug Dependence induced by Psychostimulants

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Chapter 8??? Psychostimulants

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PART 5: Cocaine Dependence - Experimental Study

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Chapter 9???Inhibitory effects of ibogaine on cocaine self-administration in rats?

SLT Cappendijk and MR Dzoljic European Journal of Pharmacology 241: 261-265, 1993?

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Modulators of drug dependence phenomena

Concluding remarks?

Suggestions for further research

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